Inhibitory effect of cardiac muscle cell lysate of neonate rat on S-180 mice-transplanted tumor in vivo

Objective To expore the inhibitory effect of the cardiac muscle cell lysate of neonate rat(CMCLnr) on S-180 mice-transplanted tumor in vivo.Methods To prepare cardiac muscle cell lysate of neonate rat(CMCLnr).And then to establish the modal of mice bearing S-180 cancer cells,using the DDP as the positive control and the 0.9%NS as the negative control,CMCLnr were divided into 30mg/kg,60mg/kg,90rog/kg,respectively.The mice were treated by i.p.injection by the test materials with corresponding dose.And then to observe the effect of different groups on S-180 mice-transplanted tumor.Results The innoculation survival rate of S 180 mice-transplanted tumor were 100%.The time of the tumor-formation in CMCLnr with different dose were later than that in 0.9%NS(P0.05).The differences in tumor weights of mice were statistically significant(P0.001).The inhibitory rate of tumor in DDP group,CMCLnr30mg/kg group,CMCLnr60mg/kg group,CMCLnr 90mg/kg group were 81.23%,63.09%,65.44% and 66.06%,respectively.And there were not obviously dose dependent in CMCLnr groups.The weight of mice increase in CMCLnr groups with different dose were more than that in 0.9%NS,but DDP inhibited the growth of mice(P0.05).Conclusion The CMCLnr can inhibit the growth of S-180 mice-transplanted tumor in vivo without side effect.