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Effect of Intervention Therapy Based on Liver-spleen Correlation Theory on Intestinal Mucosal Barrier Function in Patients with Chronic Severe Hepatitis

Peiwu Li

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Abstract

Objective To observe the therapeutic effect of intervention therapy based on liver-spleen correlation theory for chronic severe hepatitis,and to investigate its preventive effect on intestinal mucosal barrier function of the patients with chronic severe hepatitis.Methods Sixty chronic severe hepatitis patients were equally randomized into two groups.The treatment group was given routine basic treatment and Chinese herbal medicine with the actions of cooling blood and removing toxicity,strengthening spleen and replenishing Qi.The control group was given routine basic treatment and Chinese herbal medicine with the actions of cooling blood and removing toxicity.Two weeks constituted one treatment course,and the treatment lasted 2 courses.The scores of symptoms and serological parameters were examined before and after treatment,and the total effective was evaluated after treatment.Meanwhile,the intestinal mucosal permeability parameters of serum diamine oxidase(DAO) and evacuation ratio of urine lactulose and mannitol(L/M) as well as plasma endotoxin level were detected in the two groups.Results The total effective rate was 80.0% in the treatment group,which was superior to 66.7% in the control group,and there were significant differences between the two groups(P0.05).The clinical symptoms of two groups were relieved to various degrees,liver function was improved,and thrombinogen activity was promoted,the differences being significant between the two groups(P0.05).The differences of plasma endotoxin level and the ratio of L/M were insignificant between the two group before treatment(P0.05).After treatment,plasma endotoxin level and the ratio of L/M were decreased in the two groups(P0.05 compared with those before treatment),and the decrease was obvious in the treatment group(P0.05 compared with that in the control group).Conclusion Intervention therapy based on liver-spleen correlation theory can increase the therapeutic effect of chronic severe hepatitis patients,and can improve intestinal mucosal barrier function and intestinal endotoxemia of the patients with chronic severe hepatitis.

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What this paper is about

Objective To observe the therapeutic effect of intervention therapy based on liver-spleen correlation theory for chronic severe hepatitis,and to investigate its preventive effect on intestinal mucosal barrier function of the patients with chronic severe hepatitis.Methods Sixty chronic severe hepatitis patients were equally randomized into two groups.The treatment group was given routine basic treatment and Chinese herbal medicine with the actions of cooling blood and removing toxicity,strengthening spleen and replenishing Qi.The control group was given routine basic treatment and Chinese herbal medicine with the actions of cooling blood and removing toxicity.Two weeks constituted one treatment course,and the treatment lasted 2 courses.The scores of symptoms and serological parameters were examined before and after treatment,and the total effective was evaluated after treatment.Meanwhile,the intestinal mucosal permeability parameters of serum diamine oxidase(DAO) and evacuation ratio of urine lactulose and mannitol(L/M) as well as plasma endotoxin level were detected in the two groups.Results The total effective rate was 80.0% in the treatment group,which was superior to 66.7% in the control group,and there were significant differences between the two groups(P0.05).The clinical symptoms of two groups were relieved to various degrees,liver function was improved,and thrombinogen activity was promoted,the differences being significant between the two groups(P0.05).The differences of plasma endotoxin level and the ratio of L/M were insignificant between the two group before treatment(P0.05).After treatment,plasma endotoxin level and the ratio of L/M were decreased in the two groups(P0.05 compared with those before treatment),and the decrease was obvious in the treatment group(P0.05 compared with that in the control group).Conclusion Intervention therapy based on liver-spleen correlation theory can increase the therapeutic effect of chronic severe hepatitis patients,and can improve intestinal mucosal barrier function and intestinal endotoxemia of the patients with chronic severe hepatitis.

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Available abstract

Objective To observe the therapeutic effect of intervention therapy based on liver-spleen correlation theory for chronic severe hepatitis,and to investigate its preventive effect on intestinal mucosal barrier function of the patients with chronic severe hepatitis.Methods Sixty chronic severe hepatitis patients were equally randomized into two groups.The treatment group was given routine basic treatment and Chinese herbal medicine with the actions of cooling blood and removing toxicity,strengthening spleen and replenishing Qi.The control group was given routine basic treatment and Chinese herbal medicine with the actions of cooling blood and removing toxicity.Two weeks constituted one treatment course,and the treatment lasted 2 courses.The scores of symptoms and serological parameters were examined before and after treatment,and the total effective was evaluated after treatment.Meanwhile,the intestinal mucosal permeability parameters of serum diamine oxidase(DAO) and evacuation ratio of urine lactulose and mannitol(L/M) as well as plasma endotoxin level were detected in the two groups.Results The total effective rate was 80.0% in the treatment group,which was superior to 66.7% in the control group,and there were significant differences between the two groups(P0.05).The clinical symptoms of two groups were relieved to various degrees,liver function was improved,and thrombinogen activity was promoted,the differences being significant between the two groups(P0.05).The differences of plasma endotoxin level and the ratio of L/M were insignificant between the two group before treatment(P0.05).After treatment,plasma endotoxin level and the ratio of L/M were decreased in the two groups(P0.05 compared with those before treatment),and the decrease was obvious in the treatment group(P0.05 compared with that in the control group).Conclusion Intervention therapy based on liver-spleen correlation theory can increase the therapeutic effect of chronic severe hepatitis patients,and can improve intestinal mucosal barrier function and intestinal endotoxemia of the patients with chronic severe hepatitis.

Key concepts: Medicine, Diamine oxidase, Gastroenterology, Internal medicine, Spleen, Liver function, Intestinal permeability, Lactulose

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Effect of Intervention Therapy Based on Liver-spleen Correlation Theory on Intestinal Mucosal Barrier Function in Patients with Chronic Severe Hepatitis — Research Paper | ScholarLens