2005•Zhongguo linchuang yaolixue yu zhiliaoxueRequires access

Study of chloride channel ClC-3 gene expression in patient with atrial fibrillation

HU Xi-zhong

Abstract

AIM: To investigate alterations in gene expression of chloride channel ClC-3 in patients with atrial fibrillation (AF). METHODS: Right atrial appendages specimen were obtained from 33 patients with chronic AF(CAF group), 7 with paroxysmal AF(PAF group) and 31 matched controls in sinus rhythm (SR group) who underwent open-heart surgery. In this study, the semi-quantitative polymerase chain reaction (RT-PCR) was used to examine the mRNA expression of ClC-3 channel in atrial tissue. RESULTS: The content of ClC-3 mRNA in CAF group was higher than that in SR group(P 0.01), and it was correlated with AF duration (r= 0.376,P= 0.001).There was no significant difference in the gene expression of ClC-3 between PAF group and SR group, although the content of ClC-3 mRNA was slightly higher than that in SR group (P 0.05). CONCLUSION: The increased gene expression of chloride channel ClC-3 may be served as the molecular basis of I_ Cl.VOL remodeling in patients with atrial fibrillation (AF).

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Key concepts: Atrial fibrillation, Sinus rhythm, Chloride channel, Internal medicine, Gene expression, Cardiology, Messenger RNA, Real-time polymerase chain reaction