~(99)Tc~m-MAA scintigraphy of venous thrombus in rabbit models

Objective To observe the accuracy of 99 Tcm macroaggregated albumin(99 Tcm-MAA)scintigraphy of venous thrombus in rabbit models.Methods Twenty New Zealand rabbits were divided into thrombus group(n=15)and control group(n=5).Inferior vena cava(IVC)thrombus models were established in thrombus group with open surgical operation,while sham operation was performed in control group.Images were obtained after 99 Tcm-MAA injection via the right low extremity vein.The ratio of thrombus to background in the thrombus group was calculated,while in control group the ratio of corresponding area of thrombus to background was calculated.Paraffin slices of thrombus were stained with Hematoxylin-eosin(HE).Results IVC thrombus models were successfully established in 13rabbits of thrombus group.99 TcmMAA uptake in thrombi were clearly visualized in 8rabbits,while negative results were obtained in 5rabbit models in thrombus group.All rabbits of control group also showed negative images.The thrombus to background ratio(4.06±0.49)in thrombus group were higher than the corresponding area of the thrombus to background ratio(2.27±0.24)in control group(t=5.629,P0.05).All IVC thrombi of thrombus group were confirmed fresh mixed thrombi by Hematoxylin-eosin stains.Conclusion The venous thrombus could be imaged by 99 Tcm-MAA scintigraphy in rabbit IVC thrombus models,but the accuracy was relatively low.