Clinical observation of 25 cases of lung squamous cell carcinoma with late course accelerated hyperfractionated radiotherapy

Objective To observe the effect of late course accelerated hyperfractionated radiotherapy on lung squamous cell carcinoma.Methods Forty-six patients with lung squamous cell carcinoma were randomized into two groups.The conventional fractionation(CF) group received routine radiotherapy 2.0 Gy per day,5 times a week to a total dose of 70.0 Gy.The late course accelerated hyperfractionated(LCAHF) group received routine radiotherapy before 40.0 Gy,and after that,received the radiotherapy 1.5Gy twice a day with an interval of more than 6 hours between fractions to a total dose of 70.0Gy.Both group were treated by 6～8 MV X-ray.Results Local tumor control rate of CF group was not different from that of LCAHF group at the end of radiotherapy.The 1-,2-year local tumor control rates of LCAHF group were significantly improved compared to CF group,being 56%,32% VS 27.5% 13.8%,respectively(P0.05).The 1-year surival rate was 64% in LCAHF group and 44.8% in CF group(P0.05).The 2-year survival rate was 44% in LCAHF group and 17.2%in CF group (P0.05).There were no significant difference in acute radiotherapeutic response between the two groups(P0.05) Conclusion LCAHF radiotherapy on lung squamous cell carcinoma can improve 1-,2-year local tumor control rate and 2-year survival rate without increasing acute radiotherapeutic responses.Local relapse and metastasis are two major factors causing deaths.