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THE EFFECT OF THE EXPERIMENTAL LEAD EXPOSURE ON EXPRESSION OF nNOS mRNA IN THE MOUSE HIPPOCAMPUS

Feng Chen

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Abstract

Objective To study the effects of lead exposure on expression of nNOS gene in the mouse hippocampus, and to investigate the molecular toxicological mechanism affected on the learning and remember by lead expeure. Methods Using the reverse transcrip- tion-polymerase chain reaction (RT-PCR)method, as a hamipuantity assay, nNOS mRNA levels in the hippocampus of normal and lead exposure two, four, eight weeks mice were investigated. Results nNOS mRNA presented in the normal mouse hippeampus, nNOS mR- NA levels in the hippocampus were markedly decreased by lead exposure two weeks and gradually further decreased with lead exposure time increasing. Conclusion Lead can affect the expression of nNOS gene in the mouse hippocampus with a decrease in a index way fol- lowing the time of lead exposure.

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What this paper is about

Objective To study the effects of lead exposure on expression of nNOS gene in the mouse hippocampus, and to investigate the molecular toxicological mechanism affected on the learning and remember by lead expeure. Methods Using the reverse transcrip- tion-polymerase chain reaction (RT-PCR)method, as a hamipuantity assay, nNOS mRNA levels in the hippocampus of normal and lead exposure two, four, eight weeks mice were investigated. Results nNOS mRNA presented in the normal mouse hippeampus, nNOS mR- NA levels in the hippocampus were markedly decreased by lead exposure two weeks and gradually further decreased with lead exposure time increasing. Conclusion Lead can affect the expression of nNOS gene in the mouse hippocampus with a decrease in a index way fol- lowing the time of lead exposure.

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Available abstract

Objective To study the effects of lead exposure on expression of nNOS gene in the mouse hippocampus, and to investigate the molecular toxicological mechanism affected on the learning and remember by lead expeure. Methods Using the reverse transcrip- tion-polymerase chain reaction (RT-PCR)method, as a hamipuantity assay, nNOS mRNA levels in the hippocampus of normal and lead exposure two, four, eight weeks mice were investigated. Results nNOS mRNA presented in the normal mouse hippeampus, nNOS mR- NA levels in the hippocampus were markedly decreased by lead exposure two weeks and gradually further decreased with lead exposure time increasing. Conclusion Lead can affect the expression of nNOS gene in the mouse hippocampus with a decrease in a index way fol- lowing the time of lead exposure.

Key concepts: Hippocampus, Messenger RNA, Lead exposure, Real-time polymerase chain reaction, Gene expression, Lead (geology), Molecular biology, Chemistry

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