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2011•Shandong yiyaoRequires access

Expression and significance of NF-κB,MMP-1/TIMP-1 in intervertebral disc degeneration

Xu Wang

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Abstract

Objective To investigate the roles of the expression of nuclear factor kappa B(NF-κB),matrix metalloproteinases-1(MMP-1) and tissue inhibitors of metalloproteinase-1(TIMP-1) in the degeneration of intervertebral disc.Methods Tirty-eight patients with intervertebral disc degeneration from surgical intervention for cervical disc herniation(observed group) and 8 cases of normal disc tissue(control group) were involved,the expression of NF-κB,MMP-1 and TIMP-1 in disc-tissue were tested by immunohistochemistry method and ELISA,the MMP-1/TIMP-1 was calculated.Results The expression of NF-κB,MMP-1/TIMP-1 in observed group were both higher than those in the control group,both P0.05.Conclusion NF-κB and MMP-1/TIMP-1 may have important effects in the process of intervertebral disc degeneration.

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Objective To investigate the roles of the expression of nuclear factor kappa B(NF-κB),matrix metalloproteinases-1(MMP-1) and tissue inhibitors of metalloproteinase-1(TIMP-1) in the degeneration of intervertebral disc.Methods Tirty-eight patients with intervertebral disc degeneration from surgical intervention for cervical disc herniation(observed group) and 8 cases of normal disc tissue(control group) were involved,the expression of NF-κB,MMP-1 and TIMP-1 in disc-tissue were tested by immunohistochemistry method and ELISA,the MMP-1/TIMP-1 was calculated.Results The expression of NF-κB,MMP-1/TIMP-1 in observed group were both higher than those in the control group,both P0.05.Conclusion NF-κB and MMP-1/TIMP-1 may have important effects in the process of intervertebral disc degeneration.

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Available abstract

Objective To investigate the roles of the expression of nuclear factor kappa B(NF-κB),matrix metalloproteinases-1(MMP-1) and tissue inhibitors of metalloproteinase-1(TIMP-1) in the degeneration of intervertebral disc.Methods Tirty-eight patients with intervertebral disc degeneration from surgical intervention for cervical disc herniation(observed group) and 8 cases of normal disc tissue(control group) were involved,the expression of NF-κB,MMP-1 and TIMP-1 in disc-tissue were tested by immunohistochemistry method and ELISA,the MMP-1/TIMP-1 was calculated.Results The expression of NF-κB,MMP-1/TIMP-1 in observed group were both higher than those in the control group,both P0.05.Conclusion NF-κB and MMP-1/TIMP-1 may have important effects in the process of intervertebral disc degeneration.

Key concepts: Intervertebral disc, Matrix metalloproteinase, Immunohistochemistry, Degeneration (medical), Pathology, Medicine, NF-κB, Matrix (chemical analysis)

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Expression and significance of NF-κB,MMP-1/TIMP-1 in intervertebral disc degeneration — Research Paper | ScholarLens