SOCS3 and BCR-ABL fusion gene negative myeloproliferative diseases

Several cytokines induce the expression of the suppressor of cytokine signaling(SOCS)gene through JAK/STAT pathway,while SOCS protein negatively regulates signal transduction of cytokine pathway,and a negative feedback loop of cytokine signal transduction is thus completed.In BCR-ABL fusion gene negative myeloproliferative diseases,the discovery of JAK2V617F point mutation is an important landmark.Recently,it was demonstrated that JAK2V617F point mutation accompanied with highexpression of SOCS3.However,it is not clear why JAK2V617F mutant could escape the negative regulation by suppressor of cytokine signaling 3 in some of MPD patients.