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2010•Journal of Oral and Maxillofacial SurgeryRequires access

Immunohistochemical Analysis of NGF and Its Receptor Trk-A Expression in Human Salivary Adenoid Cystic Carcinoma

De-Bao Jing

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Abstract

Objective:To study the expression of NGF and its receptors Trk-A and their possible pathological mechanism of neural invasion of ACC.Methods:45 cases of salivary adenoid cystic carcinoma were retrospectively studied by envision immunohistochemistry and semi-quantitative pathology technique.Results:The expression of NGF, and its receptor Trk-A on cribriform type and tubular type ACC was more intense than on solid type.The expression of NGF and its receptor Trk-A in the group of neural invasion was more intense than those of no neural invasion.But there was no significant difference between the group of infiltration and the group of metastasis.Conclusion:NGF and its receptor Trk-A may regulate the differentiation of ACC.The action of NGF and Trk-A may be strongly related to invasion potential of ACC.

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What this paper is about

Objective:To study the expression of NGF and its receptors Trk-A and their possible pathological mechanism of neural invasion of ACC.Methods:45 cases of salivary adenoid cystic carcinoma were retrospectively studied by envision immunohistochemistry and semi-quantitative pathology technique.Results:The expression of NGF, and its receptor Trk-A on cribriform type and tubular type ACC was more intense than on solid type.The expression of NGF and its receptor Trk-A in the group of neural invasion was more intense than those of no neural invasion.But there was no significant difference between the group of infiltration and the group of metastasis.Conclusion:NGF and its receptor Trk-A may regulate the differentiation of ACC.The action of NGF and Trk-A may be strongly related to invasion potential of ACC.

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Available abstract

Objective:To study the expression of NGF and its receptors Trk-A and their possible pathological mechanism of neural invasion of ACC.Methods:45 cases of salivary adenoid cystic carcinoma were retrospectively studied by envision immunohistochemistry and semi-quantitative pathology technique.Results:The expression of NGF, and its receptor Trk-A on cribriform type and tubular type ACC was more intense than on solid type.The expression of NGF and its receptor Trk-A in the group of neural invasion was more intense than those of no neural invasion.But there was no significant difference between the group of infiltration and the group of metastasis.Conclusion:NGF and its receptor Trk-A may regulate the differentiation of ACC.The action of NGF and Trk-A may be strongly related to invasion potential of ACC.

Key concepts: Trk receptor, Medicine, Adenoid cystic carcinoma, Immunohistochemistry, Pathology, Adenoid, Receptor, Pathological

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Immunohistochemical Analysis of NGF and Its Receptor Trk-A Expression in Human Salivary Adenoid Cystic Carcinoma — Research Paper | ScholarLens