ScholarLens Back to search
2003•Unpublished venueRequires access

Immunohistochemical Study of Nonfunctioning Islet Cell Tumor

Weiming Zhang

Open publisher page 0 citations

Abstract

Objective: To study the expression of chromogranin, synaptophysin and neuron-specific enolase in nonfunctioning islet cell tumors. Methods: Fourteen paraffin-embedded specimens with nonfunctioning islet tumors were recruited from Jan 1988 to Jun 2001. The S-P method was used for the detection of chromogranin, synaptophysin and neuron-specific enolase. Results: There were positive expression of chromogranin, synaptophysin and neuron-specific enolase in 12, 8 and 12 cases saperatively. Conclusion: Non-functioning islet cell tumor can synthesize and secrete more than one hormone; CG,Syn and NSE may be ideal markers, those markers were altogether detected to promote the sensitivity.

About this research paper

What this paper is about

Objective: To study the expression of chromogranin, synaptophysin and neuron-specific enolase in nonfunctioning islet cell tumors. Methods: Fourteen paraffin-embedded specimens with nonfunctioning islet tumors were recruited from Jan 1988 to Jun 2001. The S-P method was used for the detection of chromogranin, synaptophysin and neuron-specific enolase. Results: There were positive expression of chromogranin, synaptophysin and neuron-specific enolase in 12, 8 and 12 cases saperatively. Conclusion: Non-functioning islet cell tumor can synthesize and secrete more than one hormone; CG,Syn and NSE may be ideal markers, those markers were altogether detected to promote the sensitivity.

Why it matters

A significance statement is not available in the OpenAlex record.

Key contribution

A contribution statement is not available in the OpenAlex record.

Method / approach

Method details are not available in the OpenAlex metadata.

Main findings

Findings are not separately available in the OpenAlex metadata.

Limitations

Limitations are not available in the OpenAlex metadata.

Applications

Application details are not available in the OpenAlex metadata.

Available abstract

Objective: To study the expression of chromogranin, synaptophysin and neuron-specific enolase in nonfunctioning islet cell tumors. Methods: Fourteen paraffin-embedded specimens with nonfunctioning islet tumors were recruited from Jan 1988 to Jun 2001. The S-P method was used for the detection of chromogranin, synaptophysin and neuron-specific enolase. Results: There were positive expression of chromogranin, synaptophysin and neuron-specific enolase in 12, 8 and 12 cases saperatively. Conclusion: Non-functioning islet cell tumor can synthesize and secrete more than one hormone; CG,Syn and NSE may be ideal markers, those markers were altogether detected to promote the sensitivity.

Key concepts: Chromogranin A, Synaptophysin, Enolase, Islet, Immunohistochemistry, Insulinoma, Biology, Pathology

Related papers

Related paper 1Related paper 2Related paper 3
Back to paper searchBrowse research topicsOriginal source
Immunohistochemical Study of Nonfunctioning Islet Cell Tumor — Research Paper | ScholarLens