Application of FibroScan for Diagnosis of Liver Fibrosis in Patients with Chronic Hepatitis B

Objective To investigate the value of FibroScan for diagnosis of liver fibrosis in patients with chronic hepatitis B(CHB). Methods Totally 134 CHB patients between April and December 2011 in our hospital were enrolled in this study.All of them underwent liver stiffness measurement(LSM)by FibroScan before one week of liver biopsy.With liver biopsy as the gold standard,the liver fibrosis was staged.The correlation between fibrosis stage and LSM was analyzed,and the receive operating characteristic(ROC)curve was adopted to analyze the accuracy of FibroScan for diagnosing liver fibrosis. Results LSM showed significant difference among patients with different fibrosis stages(F=91.464,P=0.000);Meanwhile,significant differences were also noted between the adjacent groups(P0.01).Spearman correlation showed positive correlation(r=0.826,P0.01).When FibroScan was applied for the assessment of liver fibrosis,the ROC area under the curve,sensitivity,specificity,and cut-off value were 0.92,0.94,0.90,and 4.60 kPa for the patients with S1～S4,0.93,0.88,0.85,and 7.60 kPa for those with S2～S4,0.97,0.94,0.91,and 9.40 kPa for those with S3～S4,and 0.96,1.00,0.88,and 13.20 kPa for those with S4. Conclusion As a noninvasive approach,FibroScan is valuable for the diagnosis of liver fibrosis in CHB patients.