Comparison of neuromuscular blockade effects of rocuronium,vecuronium and atracurium on rapid endotracheal intubation

Objective To compare the neuromuscular blockade effect and side effect of rocuronium,vecuronium and atracurium on rapid endotracheal intubation.Methods One hundred and twenty patients were randomized to four groups(n=30):Ⅰa group(rocuronium,0.6 mg/kg),Ⅰb group(rocuronium,0.9 mg/kg),Ⅱ group(vecuronium,0.1 mg/kg),Ⅲ group(atracurium,0.5 mg/kg).All patients were anesthetized with intravenously injection of midazolam(0.06 mg/kg),fentanyl(4 μg/kg),propofol(2 mg/kg) and muscular relaxants.Then the neuromuscular blockade and side effects of groups were observed.Results The onset and recovery time of Ⅰ group were shorter than other groups significantly.The intubation situation of Ⅰ group was better,and the side effects were less than Ⅱ and Ⅲ groups.Conclusion Compared with vecuronium and atracurium,rocuronium is quick in onset and recovery,and has little side effect.It is a good relaxant for rapid endotracheal intubation.