Investigation on biocompatibility of biliary stent materials

The newly developed biliary stent should have good mechanical properties,as well as excellent biocompatibility in order to meet the needs of reducing immunological reaction in vivo.In this work,Ti-O film was deposited on 316L stainless steel(316L SS) by unbalanced magnetron sputtering device,and the structure of Ti-O film was characterized by X-ray diffraction(XRD).The interaction of Ti-O film and bile was also investigated by incubating in human fresh bile.The results showed that the surface of Ti-O film could reduce bacteria adherence and form bacterial biofilm owing to more surface energy.The mesobilirubin reducing and the change of the stability of bile are other factors of evaluating biocompatibility.It's important to develop new biliary stent materials based on its biocompatibility.