2012•Journal of Emergency in Traditional Chinese MedicineRequires access
Study on Interference of Shengdihuang Granule on the Expression of Nogo-A Protein in the Rats Following Cerebral Ischemia
Zhonghua Wu
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Abstract
Objective: To observe the effects of Shengdihuang granules on the expression of neuron growth inhibitors Nogo-A protein in the rats following cerebral ischemia.Methods: All of the rats were randomly divided into 3 groups,i.e drug group(Group A),model group(Group B) and Sham-operated Group(Group C).The MCAO model rats were administered by gastrogavage with solutions of Shengdihuang granule.The expression of Nogo-A were recorded respectively in different time(3,7,14 day) following cerebral ischemia by Western Blot.Results: The MCAO model rats had the higher expression trend for Nogo-A protein following cerebral ischemia,Nogo-A ascended firstly,then decended with time.The highest expression of Nogo-A protein appeared in the seventh day.Compared with the model group,the expression of Nogo-A in the drug group rats decreased in different three time-points,had the trend of ascending first then recovering slowly.Compared with the model group,Shengdihuang had the significant down-regulation effects on the expression of Nogo-A in the rats following cerebral ischemia 14 days later.Conclusions: Shengdihuang granule can,to some extent,down-regulates the increasing expression of Nogo-A protein caused by MCAO model,and be helpful for nerve regeneration following cerebral ischemia in central nervous system.