2008•Proceeding of Clinical MedicineRequires access

The expression and clinical significance of survivin genes in acute leukemia

Tao Yang

Abstract

Objective:To investigate the expression of Survivin mRNA in acute leukemia and the prognostic significance in AL.Methods:The expression of survivin mRNA was measured in 64 AL patients with semi-quantity reverse transcription RT-PCR.Fou adults were tested as normal control(NC) and K562,NB4 cell lines were also tested as positive control.Results:The positive rates of Survivin was higher than NC.The expression of Survivin in de novo AL was higher than that in NC,while it decreased in complete remission(CR) patients.In relapsed patients the expression of survivin increased again.In AL patients,the CR rate of Survivin positive cases was lower than that of Survivin negative cases.Conclusion:Abnormal expression of Survivin genes was related to pathogenesis and progression of AL and it can serve as a marker of relapse and poor prognosis in AL.

About this research paper

What this paper is about

Why it matters

A significance statement is not available in the OpenAlex record.

Key contribution

A contribution statement is not available in the OpenAlex record.

Method / approach

Method details are not available in the OpenAlex metadata.

Main findings

Findings are not separately available in the OpenAlex metadata.

Limitations

Limitations are not available in the OpenAlex metadata.

Applications

Application details are not available in the OpenAlex metadata.

Available abstract

Key concepts: Survivin, Clinical significance, Acute leukemia, Pathogenesis, Gene, Leukemia, Medicine, Gene expression