Effects of mifepristone compound on the receptors of estrogen and progesterone in early pregnancy deciduas.

The aim was to examine the effect of mifepristone compound (mifepristone plus anordrin) on estrogen receptors (ER) and progesterone receptors (PR) in early pregnancy decidua. A controlled study was carried out among 60 normal early pregnant volunteers (49 or fewer days) in the Department of Obstetrics and Gynecology at Peking Union Medical Hospital. The concentrations of ER and PR were measured by radioligand and were compared with the control subjects after oral administration of mifepristone or mifepristone compound in different doses. The concentration of PR decreased while that of ER increased significantly in the decidua of all subjects administered mifepristone compound. The authors also found the concentration of EcR in Group 5 (mifepristone 30 mg + AF-53 5 mg) to be the highest among 6 groups. The compound may favor estrogens action on the endometrium. The results indicate that mifepristone compound with AF-53 has a coordinated function and can change the proportion of PR and ER. Hence it can facilitate abortion. The compound dose of mifepristone 30 mg + AF-53 5 mg favors the endometrium recovering. (authors modified)