Bile Bacteria Distribution and Drug Susceptibility in Patients with Biliary Infections

Objective To investigate the distribution and bile antimicrobial resistance of pathogenic bacteria in patients with biliary infections,and to guide clinical rational antimicrobial choice.Methods Bile bacterial culture and drug sensitive test were conducted in 142 specimens,and statistical analysis was performed.Results 73 strains of pathogenic bacteria were detected,with the positive rate 51.4%.The pathogens wer as follows: escherichia coli(49.3%),pseudomonas eruginosa(17.8%),pneumoniae Klebsiella bacteria(9.6%) and enterococcus(13.7%);positive rate of ESBLs producing Escherichia coli and pneumoniae Klebsiella were 36.1% and 28.6%,respectively;resistant rate of main gram-negative bacteria to imipenem was 0,followed by Amikacin,Piperacillin/tazobactam(30%),which was the most resistant to ampicillin,with high antimicrobial resistance to other common antibiotics.Enterococcus showed low resistant to vancomycin,imipenem and Teicoplanin,followed by levofloxacin,gentamycin,levofloxacin and ampicillin.Antimicrobial resistance was more than 60% to other antibiotics.Conclusion In the bile,pathogenic escherichia coli,pseudomonas aeruginosa,and pneumonia Klebsiella bacteria and enterococcus were more frequent,ESBLs resistant strains were significantly higher than the non-ESBLs strains;Enterococcus resistance was low.Clinical reasonable application of antimicrobial drugs should be based on the drug sensitive results.