Peri-operative analgesia with flurbiprofen and fentanyl:clinical efficacy and safety

Objective To assess the efficiency and safety of flurbiprofen combined with fentanyl for perioperative analgesia.Methods One hundred and ninety-two patients were randomly assigned to four groups. Group A.Postoperatively,fentanyl 1 mg+0.9%NaCl to 100 mL.Group B:Flurbiprofen 50 mg was injected preoperatively.Postoperatively,fentanyl 1 mg+0.9%NaCl to 100 mL.Group C:Flurbiprofen 50 mg was injected preoperatively.Postoperatively,flurbiprofen 100 mg+ fentanyl 0.5 mg+0.9%NaCl to 100 mL.Group D:Flurbiprofen 50 mg was injected preoperatively.Postoperatively,flurbiprofen 150 mg+fentanyl 0.5 mg+ 0.9%NaCl to 100 mL.Patient controlled analgesia(PCA):background dose 2 mL/h,pulse dose 2 mL, lockout time 10 min.The patients were followed up for 24 h after operation and vital signs,analgesia effect,and adverse effect were recorded.Results No significant differences were found in the age,body mass index and surgery duration among the 4 groups.The vital signs were stable within 24 h after operation.Patients in group A had higher visual analog scale(VAS)than those in the other 3 groups at regaining consciousness(all P0.05).At 4,8,and 24 h after the operation,the VAS in group A was significantly higher than those in group C and D(all P0.05);at 24 h after the surgery,the VAS in group B was higher than those in group C and D (both P0.05).The times of PCA and the amount of fentanyl in group C,D were significantly lower than those of group A,B(all P0.05).The incidence of nausea in group D was higher than those in the other three groups(all P0.05).Conclusion Peri-operative analgesia with flurbiprofen and fentanyl has a definite analgesic effect and less adverse effects,and can be safely used in the clinic.