The imaging and pathology of inflammatory myofibroblastic tumor

Objective:To investigate the imaging and pathology of inflammatory myofibroblastoma(IMT).Methods:Thirteen patients of IMT proved by pathology,in which 10 patients with contrast medium enhancement,and the imaging were analyzed retrospectively.Results:The anatomic locations included mastoid antrum(n=1),lung(n=2),mediastinum(n=2),pharynx(n=1),sinus(n=1),gastric antrum(n=1),esophagus(n=1),liver(n=1),retroperitoneum(n=1),bladder(n=2).Imaging findings were solid masses in eight cases,cystic and solid mass in 5 cases.The majority of cases have a clear boundary.After contrast administration,moderate or marked homogeneous or heterogeneous enhancement,was found.IMT occurred in the head and neck,retroperitoneal space,and 1 case of mediastinum tumor had invasive imaging features.The tumors were mainly composed of spindle shaped fibrous cells and inflammatory cells on pathology,and positive staining for muscle deriving proteins was observed immunohistochemically.Conclusion:Imaging provides accurate anatomic location and helpful information for clinical diagnosis of IMT,yet the definite diagnosis relies on pathological and immunohistochemical study.