High-Dose-Folinic Acid and 5-fluorouracil Bolus Continuous 48-Hour Infusion in the treatment of Advanced Cardiac Cancer

Objective To assess the anti-tumor efficacy and safety of high-dose-folinic acid and 5-fluorouracil bolus continuous 48-hour infusion in the treatment of advanced cardiac cancer.Methods Twenty-seven patients with advanced cardiac cancer were treated by high-dose-folinic acid and 5-fluorouracil bolus continuous 48-hour infusion.Results There were one complete esporse,ten partial response,twelve no changes and four progressive disease in the series with total response rate of 40.74%. The main side effects included nausea and vomiting,mucositis,bone marrow suppression,alopecia and diarrhea.Other side effects were uncommon.All side effects were tolerable and mild except for nausea-vomiting.Conclusions High-dose-folinic acid and 5-fluorouracil bolus plus 48-hour continuous infusion may be a safe and effective therapy for the patients with advanced cardiac cancer.