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2000•Acta Scientiae CircumstantiaeRequires access

Micronuclei induced by SO_2 derivatives in mouse bone marrow in vivo

Meng Guangmeng

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Abstract

Micronuclei (MN) induced in the polychromatophilic erythroblasts (PCE) of mouse bone marrow by SO\-2 derivatives the mixture of sodium sulfite and bisulfite (3∶1?mol/mol) were studied in vivo.It showed that the chemicals caused an increase of MN frequaencies in the PCE cells in a dose\|dependent manner.The results also indicated that SO\-2 derivatives (Na\-2SO\-3 and NaHSO\-3) singnificantly inhibited mutagen cyclophosphamide (CP)\|induced MN formation in the PCE cells of mouse bone marrow; however,the chemicals enhanced mutagen Mitomycin C (MMC) \|induced MN formation in mouse PCE cells.These results imply that SO\-2 is a clastogenic and genotoxic agent,but the effects on mutagenesis of different mutagens are various.

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What this paper is about

Micronuclei (MN) induced in the polychromatophilic erythroblasts (PCE) of mouse bone marrow by SO\-2 derivatives the mixture of sodium sulfite and bisulfite (3∶1?mol/mol) were studied in vivo.It showed that the chemicals caused an increase of MN frequaencies in the PCE cells in a dose\|dependent manner.The results also indicated that SO\-2 derivatives (Na\-2SO\-3 and NaHSO\-3) singnificantly inhibited mutagen cyclophosphamide (CP)\|induced MN formation in the PCE cells of mouse bone marrow; however,the chemicals enhanced mutagen Mitomycin C (MMC) \|induced MN formation in mouse PCE cells.These results imply that SO\-2 is a clastogenic and genotoxic agent,but the effects on mutagenesis of different mutagens are various.

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Available abstract

Micronuclei (MN) induced in the polychromatophilic erythroblasts (PCE) of mouse bone marrow by SO\-2 derivatives the mixture of sodium sulfite and bisulfite (3∶1?mol/mol) were studied in vivo.It showed that the chemicals caused an increase of MN frequaencies in the PCE cells in a dose\|dependent manner.The results also indicated that SO\-2 derivatives (Na\-2SO\-3 and NaHSO\-3) singnificantly inhibited mutagen cyclophosphamide (CP)\|induced MN formation in the PCE cells of mouse bone marrow; however,the chemicals enhanced mutagen Mitomycin C (MMC) \|induced MN formation in mouse PCE cells.These results imply that SO\-2 is a clastogenic and genotoxic agent,but the effects on mutagenesis of different mutagens are various.

Key concepts: Micronucleus test, Mutagen, Mitomycin C, Clastogen, Bone marrow, In vivo, Chemistry, Mutagenesis

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