2002•Hainan Daxue xuebao. Ziran kexue banRequires access
Changes of NO and GMP-140 in Children with Pneumonia and Its Clinical Importance
Qi Zhou
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Abstract
In this paper,the effect and clinical importance of serum NO and plasma GMP-140 in children with pneumonia were studied, and the serum NO and plasma GMP-140(Granule membrane protein-140) in 41 patients with pneumonia and 23 normal controls were measured by nitrate reductase method and double antibodies ELISA, respectively. The results showed that the levels of serum NO in the groups with pneumonia were significantly higher than those in the control group( P 0.01);the levels of serum NO in severe cases were significantly higher than those in the patients with mild symptoms;the levels of plasma GMP-140 in the groups with pneumonia were significantly higher than those in the control groups( P 0.01).Moreover , the serum NO level positively correlated with plasma GMP-140 level ( r=0 73, P 0 01). These findings indicated that there was an elevation of platelet activation in children with pneumonia, and that NO and platelet activation were associated with the inflammation and the pathological progress of pneumonia.