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Effects of PPARα on Organ Transplantation

Guangming Wang

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Abstract

Objective: To investigate the effect of PPARα on organ transplantation on mice model.Methods: Fenofibrate,Wy14643,or vehicle was given through a feeding needle once per day for 7 consecutive days on C57BL/6J,spleen from C57BL/6J or BALB/c was collected and splenocyte was isolated.Mixed lymphocyte reaction(MLR) was carried out.Results: The splenocyte was no response in MLR from the mice treated with fenofibrate,or Wy14643.Conclusion: PPARα could be activated by fenofibrate,or Wy14643,could inhibit MLR.

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What this paper is about

Objective: To investigate the effect of PPARα on organ transplantation on mice model.Methods: Fenofibrate,Wy14643,or vehicle was given through a feeding needle once per day for 7 consecutive days on C57BL/6J,spleen from C57BL/6J or BALB/c was collected and splenocyte was isolated.Mixed lymphocyte reaction(MLR) was carried out.Results: The splenocyte was no response in MLR from the mice treated with fenofibrate,or Wy14643.Conclusion: PPARα could be activated by fenofibrate,or Wy14643,could inhibit MLR.

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Available abstract

Objective: To investigate the effect of PPARα on organ transplantation on mice model.Methods: Fenofibrate,Wy14643,or vehicle was given through a feeding needle once per day for 7 consecutive days on C57BL/6J,spleen from C57BL/6J or BALB/c was collected and splenocyte was isolated.Mixed lymphocyte reaction(MLR) was carried out.Results: The splenocyte was no response in MLR from the mice treated with fenofibrate,or Wy14643.Conclusion: PPARα could be activated by fenofibrate,or Wy14643,could inhibit MLR.

Key concepts: Fenofibrate, Splenocyte, Mixed lymphocyte reaction, Transplantation, Spleen, Peroxisome proliferator-activated receptor, Organ transplantation, Medicine

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