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2008•Chinese Journal of MycologyRequires access

In vitro susceptibility test of combination of chloroquine and fluconazole on Cryptococcus neoformans

Zhu Yuanjie

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Abstract

Objective To explore in vitro combination effect of chloroquine and fluconazole on Cryptococcus neoformans.Medthod Chloroquine at different concentrations were tested with fluconazole on their effect on sminimum inhibitory concentration(MIC) and minimum fungicidal concentration(MFC) of fluconazole on 20 isolates of C.s neoforman.Result At concentrations higher than 100 μmol/L,chloroquine could obviously decrease both MIC and MFC of fluconazole on C.neoformans.Conclusions Chloroquine could enhance the ability of fluconazole against C.neoformans and they may have synergistic effect on C.neoformans.

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What this paper is about

Objective To explore in vitro combination effect of chloroquine and fluconazole on Cryptococcus neoformans.Medthod Chloroquine at different concentrations were tested with fluconazole on their effect on sminimum inhibitory concentration(MIC) and minimum fungicidal concentration(MFC) of fluconazole on 20 isolates of C.s neoforman.Result At concentrations higher than 100 μmol/L,chloroquine could obviously decrease both MIC and MFC of fluconazole on C.neoformans.Conclusions Chloroquine could enhance the ability of fluconazole against C.neoformans and they may have synergistic effect on C.neoformans.

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Available abstract

Objective To explore in vitro combination effect of chloroquine and fluconazole on Cryptococcus neoformans.Medthod Chloroquine at different concentrations were tested with fluconazole on their effect on sminimum inhibitory concentration(MIC) and minimum fungicidal concentration(MFC) of fluconazole on 20 isolates of C.s neoforman.Result At concentrations higher than 100 μmol/L,chloroquine could obviously decrease both MIC and MFC of fluconazole on C.neoformans.Conclusions Chloroquine could enhance the ability of fluconazole against C.neoformans and they may have synergistic effect on C.neoformans.

Key concepts: Cryptococcus neoformans, Fluconazole, Chloroquine, In vitro, Microbiology, Minimum inhibitory concentration, Antifungal, Biology

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