MTHFR C677T POLYMORPHISM AND ESOPHAGEAL CANCER SUSCEPTIBILITY:A META-ANALYSIS

[Objective]To evaluate the relationship between MTHFR C677T genetic polymorphism and susceptibility to esophageal cancer by use of Meta-analysis.[Methods]The literature search in CNKI,Pubmed,ScienceDirect,Springer Link was carried out to find relevant papers;disqualified studies were excluded.Odds ratio of MTHFR C677T genotype distributions in the group of patients with esophageal cancer and the group of healthy control was calculated.The Meta-analysis was applied with RevMan 4.3 software for heterogeneity test and pooled OR calculation.[Results]Of the case control studies selected for this Meta-analysis,a total of 2 162 esophageal cancer cases and 3 114 controls were included.The pooled OR values of CT and TT compared to CC were 1.47(95%CI:1.10-1.96)and 1.60(95%CI:1.07-2.39),Z statistics were 2.62 and 2.30,and their responding P values were 0.009 and 0.02.[Conclusion]There are enough current evidences to prove the relationship between MTHFR C677T genetic polymorphism and susceptibility to esophageal cancer.It is demonstrated that MTHFR C677T genotype CT and TT are the important risk factors for susceptibility to human esophageal cancer.