Literature Analysis of 63 Cases of Allergic Reaction Induced by Yuxingcao Injection

OBJECTIVE:To investigate the reasons,characteristics and rules of Yuxingcao injection-induced allergic reaction,and to promote rational drug use in the clinic.METHODS:The literatures were retrieved from Chinese Journal Full-text Database between 1994 and 2012.63 cases of Yuxingcao injection-induced allergic reaction without drug combination were collected and analyzed statistically.RESULTS:Of the 63 cases,21(33.33%)were male,42(66.67%)were female,and 53.97% were in age from 15 to 44 years;15(23.81%)had drug-induced allergic reaction history;68.25% got upper respiratory tract infection in primary disease,and 9 had no Yuxingcao injection therapy history;the proportion of typeⅠallergic reaction was the highest(96.83%);as to route of administration,1 was intramuscular infusion and 62 were intravenous infusion.Almost all of allergic reaction appeared within 20 min after medication.Allergic patients were recovered after treatment except 2 was died.CONCLUSIONS:Yuxingcao injection can induce severe even fatal allergic reaction,and its mechanism may be related to the constitution of patient,ingredient of itself and diagnosis warp.Therefore,manufacturers should further improve the safety evaluation of Yuxingcao injection and formulate the quality standard of polysorbate 80.Clinical treatment should based on syndrome differentiation in accordance with traditional Chinese medicine theory;prevention consciousness should be enhanced in clinical application.The method of skin test should be formulated.