Study on the Immunization Schedule and Dose of Genetic Recombinant Hepatitis B Vaccine Wed for Adults

Objective To study the immunization schedule and doses of genetic recombinant hepatitis B vaccine wed for adults. Methods 1168 healthy persons aged 15-60 years old with negative HBsAg,anti-HBs and anti-HBc were randomly selected Yandong and Panwan township of Sheyang county and divided into 12 groups.Recombinant yeast-derived vaccine (5Mg,10mg)and CHO recombinant vaccine (10Mg,20Mg) were vaccinated following 0,1,2 months and 0,1,6 months immunization schedule. Results One month after full dose immunization,the anti-HBs positive rates were from 72.83% to 98.99% and GMTs were from 34.45%mIU/mL to 201.08mIU/mL in all 12 groups. Six months after that,the anti-HBs positive rates were from 55.00% to 95.10% and GMTs were from 27.01mIU/mL to 81.81mIU/mL in all 12 groups. Results The anti-HBs positive rates and GMTs in different immunization programs had highly significant difference. The anti-HBs positive rates,GMT and distribution percent of high titer of children vaccinated the high dose vaccine were higher than those of children vaccinated low dose vaccine.The anti-HBs positive rates and GMT of children following 0,1,6 months immunization schedule were higher than those of children following 0,1,2 months immunization schedule.The anti-HBs positive rates and GMT of CHO recombinant vaccine were higher than those of recombinant yeast-derived vaccine.GMT induced by 10μg CHO recombinant vaccine was obviously higher than that induced by 10μg recombinant yeast-derived vaccine,but the anti-HBs positive rates had no significant differentce. Conclusion The results showed that the high dose vaccine should be used for adults.It was suggested that 20μg CHO recombinant vaccine and 0,1,6 months immunization schedule should be selected.