Relationship Between ACE I/D Gene Polymorphism and the Curative Effects of Angiotensin-converting Enzyme Inhibitor in Hypertensive Individuals

Objective To investigate responses of patients with different ACE genotype to the treatment of angiotensin converting enzyme inhibitor(ACEI). Method According to ACE gene I/D polymorphism 58 patients with hypertension were divided in II( n= 20), ID( n= 20) and DD( n= 18) groups. All patients were treated with cilazapril 2.5 mg～5 mg for 4 weeks. Blood pressure was evaluated every week after treatment. Results 2 patients were markedly effective, 12 patients were effective and effective rate was 70% in II group. In ID group 8 patients were markedly effective,8 patients were effective and effective rate was 80%. In DD group 13 patients were markedly effective,4 patients were effective and effective rate was 94%. Curative effects of cilazapril was significantly higher in DD group than ID and II groups ( P 0 01). Conclusion ACE I/D gene polymorphism can be use as one of adjunctive indicators for predicting the effect of using ACEI in treatment of patients with hypertension.