The Clinical Efficacy of Large-dosage Amiodarone in Treating Refractory Ventricular Tachycardia and/or Ventricular Fibrillation in Emergency Department

Objective: To investigate the clinical efficacy of large dose of amiodarone in treating refractory ventricular tachycardia(VT) and ventricular fibrillation(VF) in emergency department.MethodS: Fifty-six patients(36 males and 20 females,aged 37～73,46.2 on the average) with refractory VT and VF after acute myocardiac infarction were enrolled in this study.In the course of arrhythmia,loading dose of 150 mg of Amiodarone was given intravenously and the dosage of 1.0～1.5 mg/min was maintained within six hours and 0.5～1.0 mg/min was continuously given after six hours.Furthermore,Amiodarone of additional 75～150 bolus was given intravenously,with an interval of half hour,according to their conditions and amiodarone was administrated orally at the same time.Results: Average intravenous treating time of amiodarone was 2.56±0.59 days.In the first 24 hours,average amiodarone dosage was 759±38(900~2100) mg,the VT or VF of 39 patients was controlled and control rate was 69.6 %(39/56);Amiodarone dosage was 759±38(720~780)mg in second 24hours,another 7 patients,VT or VF were controlled and accumulative control rate was 82.1 %(46/56);Amiodarone dosage was 726±21(700~750)mg in the third 24 hours and the total control rate was 91.1%(51/56).Bradycardia arrhythmia was found in 7 patients and was rebounded to the normal by lower dosage.Six patients died of exacerbated conditions in 72 hours.Conclusion: The strategy of continuous intravenous infusion of a large dose amiodarone is very effective and quite safe to the patients with refractory VT and VF after AMI.