Advances in research of echinocandins drugs as antifungal agents

Echinocandins are a new class of antifungus drugs. The drugs act at the level of the fungal cell wall.The echinocandins have activity against all Candida and Aspergillus species,and have proved to be quite safe.Three echinocandins,including caspofungin,micafungin,and anidulafungin,are currently available and received approved labeling from the Food and Drug Administration.This paper summarizes the mechanism of action,antimicrobial activity,pharmacokinetics,clinical application,dosage,drug interaction,and adverse reaction.