Blood Glucose Reduction by Metformin plus Acarbose:Evaluation of the Clinical Affects and Curative Effects in Treating Type 2 Diabetes Mellitus

Objective To observe and compare the clinical affects and curative effects between using metformin and metformin plus acarbose in the treatment of type 2 diabetes mellitus(T2DM).Methods From January to October 2010,45 T2DM patients with common symptoms of easy-starving and overeating were randomized into two groups and treated for 12 weeks with either metformin(n=20) or metformin plus acarbose(n=25).Results After the treatment,significant differences were found between the two groups in the improvement on patients' sense of starving and quantity of eating(P0.05),fasting and postprandial blood glucose(P0.01),up-to-standard rate of fasting blood glucose(P0.01),and up-to-standard rate of postprandial blood glucose(P0.05).Conclusion The combination of metformin and acarbose can substantially improve the appetite and quantity of eating for patients with T2DM,hence significant reductions of fasting and postprandial blood glucose level can be feasibly achieved.