Clinical and pathological analysis of 15 cases IgA nephropathy with manifestation of nephritic Syndrome in Children

Objective To analyse clinncal and pathologic features of immunoglobulina nephropathy(IgAN) with manifestation of nephritic syndrome in children.Methods A retrospective review of 62 cases of primary IgAN within 6 years(2000～2006) were conducted based on renal biospy,tosummarize clinical manifestactions and pathological features of IgAN with manifestation of nephritic syndrome.Results According to WHO pathological changes of 1 case was grade II(6.7%),1 case with nephritis nephropathy;8 cases were grade III(53.3%),all cases with nephritis nephropathy.5 cases were grade IV(33.3%),2 cases with simple nephropathy,3 cases with nephritis.1 case was grade V(6.7%).Immunofluorescence typing IgA+C33 cases(20%),IgA+C3+IgG,1 case(6.7%)IgA+C3+IgG+IgM7 cases(46.7%),IgA+C3+IgM,3 cases(20%),IgA+IgM 1 case(6.7%),IgA+C3+IgG+IgM was frequently found.Conclusion The clinical representation and tissue damage of IgA nephropathy presenting with rephritic syndrome are serious,grades Ⅲ and Ⅳ.Pathologically and type IgA+C3+IgG+IgM immunologically are common.