Analgesia Effect of Dexamethasone Combined with Ondansetron Compared to Tramadol in radically Operated Gastric Cancer Patients

Objective To investigate the analgesic effects, postoperative nausea and vomiting of dexamethasone combined with ondansetron compared to tramadol in the radically operated gastric cancer patients. Methods 90 radically operated gastric cancer patients were randomly dividedinto three groups (A, B, C) to do a double-blind test: group A were given tramadol 1 000 mg, the drugs were infused in 0.9% sodium chloride injection, group B were given tramadol 1 000 mg plus ondansetron 8 mg, group C were given tramadol 1 000 mg plus dexamethasone 10 mg.The intravenous infusion of tramadol was 10 mg·h -1 for 10 min,and the limited dose within 4 h was 150 mg.The pain, sedation, dizziness, nausea, vomiting in the patients and the doses of tramadol and dexamethasone combined with ondansetron for 48 h were evaluated. Results The pain relief in group C was the best, group A better,and group B the third. The amount of tramadol used in group B was the biggest. The dose of tramadol had no significant difference between group A and C for 48 h. Patients in group C had the least number of nausea and vomiting, and there was no significant differences between group A and B. There was no significant difference in dizziness and sedation among three groups. Conclusion Ondansetron can’t lower the rate of nausea and vomiting in the radically operated gastric cancer patients, and had lower analgesia effect, requiring more tramadol. Dexamethasone can reduce the incidence of nausea and vomiting.