2009•PubMedRequires access
[Evaluation of promoting effect of several transdermal enhancers with fuzzy matter-element model].
Xiaoyan Zheng, Hui Wang, Kuoju Cheng, Qing Liang
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Abstract
OBJECTIVE: To investigate the utilization of fuzzy matter - element model in evaluating the promoting effects of transdermal enhancers. METHOD: Paracetamol was used as drug model. Azone, menthol, camphor, oleic acid, clove oil, Schizonepeta tenuifolia oil and patchouli were used as transdermal enhancers. Transdermal absorption experimentation of paracetamol was detected on the device of penetrating skins of rabbit in vitro and penetrating rates, steady fluxs, lag time and enhancement ratio were calculated to evaluate promoting effects of transdermal enhancers with fuzzy matter-element model based on variation coefficient weight. RESULT: Paracetamol had the best promoting function with 2% clove oil and 2% camphor. The function drops slightly with 1% azone, 2% Schizonepeta tenuifolia oil, 2% menthol and 2% oleic acid ranked behind. The worst was with 2% patchouli. CONCLUSION: Fuzzy matter-element model based on variation coefficient weight could judge the promoting and penetrating effect of transdermal enhancers objectively and feasible.