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Expression of E-cad and MMP-2 in Human Adenomyosis and Its Significance

Xuesong Han, Lin Xu, Pu Ping, Hongmei Fu, Shan Zhao-ping, Dong Wen-yi

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Abstract

Objective: To study the expression of E-cad and MMP-2 in human adenomyosis and to explore the correlation between the expression and pathogenesis of human adenomyosis.Methods: Immunohistochemical S-P method was employed to detect the expression of E-cad and MMP-2 in 30 specimens of ectopic endometrium,eutopic endometrium of adenomyosis and 16 specimens of normal endometrium.Results: The expression of E-cad in ectopic and eutopic endometrium of adenomyosis were significantly lower than those of normal endometrium(P0.01,P0.05).The expression of MMP-2 in ectopic endometrium of adenomyosis were significantly higher than those of eutopic endometrium of adenomyosis and normal endometrium(P0.01,P0.01).Conclusion: The abnormal expression of E-cad and MMP-2 might be correlated with the pathogenesis of human adenomyosis.

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What this paper is about

Objective: To study the expression of E-cad and MMP-2 in human adenomyosis and to explore the correlation between the expression and pathogenesis of human adenomyosis.Methods: Immunohistochemical S-P method was employed to detect the expression of E-cad and MMP-2 in 30 specimens of ectopic endometrium,eutopic endometrium of adenomyosis and 16 specimens of normal endometrium.Results: The expression of E-cad in ectopic and eutopic endometrium of adenomyosis were significantly lower than those of normal endometrium(P0.01,P0.05).The expression of MMP-2 in ectopic endometrium of adenomyosis were significantly higher than those of eutopic endometrium of adenomyosis and normal endometrium(P0.01,P0.01).Conclusion: The abnormal expression of E-cad and MMP-2 might be correlated with the pathogenesis of human adenomyosis.

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Available abstract

Objective: To study the expression of E-cad and MMP-2 in human adenomyosis and to explore the correlation between the expression and pathogenesis of human adenomyosis.Methods: Immunohistochemical S-P method was employed to detect the expression of E-cad and MMP-2 in 30 specimens of ectopic endometrium,eutopic endometrium of adenomyosis and 16 specimens of normal endometrium.Results: The expression of E-cad in ectopic and eutopic endometrium of adenomyosis were significantly lower than those of normal endometrium(P0.01,P0.05).The expression of MMP-2 in ectopic endometrium of adenomyosis were significantly higher than those of eutopic endometrium of adenomyosis and normal endometrium(P0.01,P0.01).Conclusion: The abnormal expression of E-cad and MMP-2 might be correlated with the pathogenesis of human adenomyosis.

Key concepts: Adenomyosis, Pathogenesis, Endometrium, Immunohistochemistry, Medicine, Matrix metalloproteinase, Pathology, CAD

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