2004•The Chinese Journal of Modern Applied PharmacyRequires access
Effects of yunnang baoyao on the expression of platelet membrane glycoproteins
Ye Jianfeng, Weimin Yan, Zhuohui Gan, Gao Chonghun, Liqun Zhang, Deliang Li, Zheng Xiaoxing
Open publisher page 2 citations
Abstract
OBJECTIVE To study the alterations of aggregation rate of platelets induced by ADP or arachidonic acid and to study the change of membrane glycoproteins of resting platelets or platelets activated by ADP after administration of Yunnang Baoyao. METHOD After SD rats were administrated with Yunnang Baoyao for three days, the platelet aggregation rate was detected by platelet aggregation analyzer, and the expression of CD41 and CD62P on platelets membrane was detected by flow cytometry. RESULTS The platelet aggregation rate of groups administrated with Yunnang Baoyao was much higher than control group (P0.01). If the platelets were activated by ADP, the expression of CD61 and CD62P on the platelets membrane in Yunnang Baoyao group was increased significantly compared with the control group. However, there was no significant change of these glycoproteins in resting platelets among groups (P0.05).CONCLUSION Yunnang Baoyao, under stimulating condition, can increase the reaction activity of platelet and the expression of CD61,CD62P on the membrane. Howerer, Yunnang Baoyao will not increase its glycoproteins expression on platelet membrane under normal condition.