Clinical Observation on 120 Cases in Treatment of Condyloma Acuminatum with Imiquimod and Carbon Dioxide Laser

Objective: To observe the effect,safety and prevention on relapse of topical application of 5% imiquimod with carbon dioxide laser on patients with condyloma acuminatum.Methods: 120 patients came from the clinic of our hospital from January 2011 to october 2011,with the diagnosis of condyloma acuminate,were randomly divided into two groups: study group and control group,60 for each.There were no differences in age,gender and course of disease.The patients in control group received carbon dioxide laser resection only,while the patients in study group received carbon dioxide laser combined with imiquimod cream for 8 weeks,which were applied three times a week at night,the follow-up time was 3 months for both groups with assessment visits every 2 weeks.The rates of cure,recurrence and adverse reactions were compared.Results: During the follow-up time after treatment,in the control group,complete clearance occurred in 53 patients and recurrence occurred in 7 patients,the cure rate and the recurrence rate was 88.33% and 11.67% respectively.In the control group,complete clearance occurred in 41 patients and recurrence occurred in 19 patients,the cure rate and the recurrence rate was 68.33% and 31.67% respectively(X2 =7.07,P 0.01).32 patients observed adverse reactions in study group and 17 patients in control group,the incidence of adverse reactions of study group and control group was 53.33% and 28.33% respectively(X2 =7.76,P0.01),side effect include erythema,edema,burning,there was no systemic side effect in two groups.Conclusion: Topical application of 5% imiquimod cream combined with carbon dioxide laser in treatment of condyloma acuminatum is effective and can significantly reduce the recurrence rate.