Study of changes in magnetic resonance spectroscopy of the brains of rats with permanent bilateral common carotid artery ligation

Objective:The study was to analyze the changes in magnetic resonance spectroscopy of the brains of rats with permanent bilateral common carotid artery.Methods:After the permanent bilateral common carotid artery ligation was modeled,the 12 rats were randomly divided into the operative group and the pseudo-operative group.There were 6 rats in each group.After 30 days,abilities of learning and memory of the two section rats were tested by using the morris water maze.Then we observed the changes of magnetic resonance spectroscopy and NAA、NAA/(Cr+Cho)in lobus temporalis of rats.Results:Abilities of learning and memory of rats were significantly poorer in the operative section than that in the pseudo-operative group.The levels of NAA、NAA/(Cr+Cho)in lobus temporalis of rats with permanent bilateral common carotid artery ligation were significantly lower in the operative section than that in the pseudo-operative group.Conclusions:The method of permanent bilateral common carotid artery ligation can obviously impair the abilities of learning and memory and lower the levels of NAA、NAA/(Cr+Cho)in lobus temporalis of rats.