The preliminary study of the clinical significance of Pax-2 expression in renal cell carcinoma

Objective To research Pax-2 expression in various types of renal cell carcinoma,and to discuss the significance of clinical diagnose and prognosis with RCC.Methods The method of immunohistochemistry SP was used to detect the expression of Pax-2 in 73 cases of renal cell carcinoma and 19 patients with normal renal tissue.The experiment analyzed the relationship between Pax-2 and pathological features of the renal cell carcinoma using immunohistochemistry SP combined with experimental data and clinical information.Results The overall positive rate of Pax-2 expression in renal cell carcinoma was 73.97%(54/73).In clear cell carcinoma,the positive expression rate was 84.85%(28/33).The positive expression in the papillary cell carcinoma was 70.00%(14/20) and 60.00%(12/20) in chromophobe renal cell carcinoma.The positive expression rate was 10.53%(2/19) in normal renal tissue.The total positive rate of renal cell carcinoma was significantly higher than that of normal renal tissue.The difference was statistically significant(χ2=25.479,P=0.0000.05).Pax-2 expression in renal cell carcinoma related with clinical stage(χ2=4.852,P=0.026),pathological grade(χ2=5.532,P=0.019) and lymph node metastasis(χ2=3.886,P=0.049),but it unrelated with gender(χ2=1.301,P=0.254),age(χ2=0.723,P=0.394) and pathological type(χ2=4.219,P=0.121).Conclusion Pax-2 could offer a molecular index for the assessment of diagnosis and prognosis in renal cell carcinoma.