Sequential invasive-noninvasive mechanical ventilation in neonatal respiratory failure

Objective Many controversial questions remain concerning the best methods for conducting the weaning process from mechanical support and from the endotracheal tube.We aimed to assess whether sequential invasive-noninvasive mechanical ventilation can increase the weaning success rate and improve the outcomes of patients with neonatal respiratory failure(NRF) compared with conventional mechanical ventilation.Methods A prospective randomized trial was conducted at the intensive care unit(ICU) over 2 years included 34 patients with NRF.Thirty-four patients were randomly assigned to therapy group(n=17) and control group(n=17),the therapy group was treated by sequential invasive-noninvasive mechanical ventilation and the control group was treated by conventional weaning mode.The two groups were compared by determing the weaning success rate,time of oxygen requirement and the incidence of apnea and funnalchest.Results The weaning success rate was 94.1% in therapy group versus 70.6% in control group(P0.05).The time of oxygen requirement was(15±6)days in therapy group versus(21±8)days in control group(P0.05).The incidence of apnea and funnalchest were 5.9% and 0 in therapy group versus 23.5% and 17.6% in control group(P0.05).Conclusion Compared with conventional weaning from mechanical ventilation,Sequential invasive-noninvasive mechanical ventilation is more effective in treating patients with NRF.It can increase the weaning success rate and decrease complications of patients.