Association of Rs2383206 Single Nucleotide Polymorphism on Chromosome 9p21 and Cerebral Infarction in Chinese Han

Objective To investigate the association of rs2383206 single nucleotide polymorphism(SNP) on chromosome 9p21 and cerebral infarction in northern Chinese Han population. Methods Three hundred and fifty-five cases of patients with early cerebral infarction(C1 group) and 430 cases of surgical patients hospitalized over the same period as controls.PCR-SNP Stream technology was used to genotype rs2383206 polymorphism,and genotyping results were statistically analyzed. Results The frequency of genotype AG of rs2383206 was increased in C1 group,compared with control group,P=0.007).G allele frequency of rs2383206 was also higher in C1 group than control group.After adjusting for confounding factors,we found that,compared with AA homozygotes of the rs2383206,GG/GA genotype has significant effect to increase the risk of cerebral infarction(adjusted OR 1.23,95%CI 1.11-2.05,P=0.009).rs2383206 G-allele increased the risk of large artery atherosclerotic stroke by 2.09 times. Conclusion Rs2383206 is the susceptible locus to CI in Chinese Hans.