2008•Journal of Clinical Emergency CallRequires access

Effect of Pentoxifylline on Surfactant in Lungs of Rat with Acute Lung Injury

Xiao‐Nan Tao

Abstract

Objective To investigate the effect of pentoxifylline (PTX) in treating rats with acute lung injury. Methods LPS induced acute lung injury in rats,Blood gas was analysed,PLA_2 and the surfactant in bronchoaveoli (BALF) was lavaged at 30h after LPS injection.Results LPS induced acute lung injury in rats.PLA_2 in BALF and lung tissue were obviously higher(P0.01),PC decreased while PE increased (P0.01).The changes of above parame- ters were obviously attenuated by PTX.Conclusion The changes of PS system in lung tissue is definitely in ALl.Changes of PLA_2 is consistent in that of surfactant and may play an important role in this change.PTX has certain protective effects on rat with ALI.

About this research paper

What this paper is about

Why it matters

A significance statement is not available in the OpenAlex record.

Key contribution

A contribution statement is not available in the OpenAlex record.

Method / approach

Method details are not available in the OpenAlex metadata.

Main findings

Findings are not separately available in the OpenAlex metadata.

Limitations

Limitations are not available in the OpenAlex metadata.

Applications

Application details are not available in the OpenAlex metadata.

Available abstract

Key concepts: Pentoxifylline, Medicine, Pulmonary surfactant, Lung, Pharmacology, Anesthesia, Internal medicine, Thermodynamics