The protective effects of cerebral ischemia pretreatment on the cerebral ischemia reperfusion injuries

Objective To observe the protective effects of cerebral ischemic pretreatment on the following cerebral ischemic reperfusion injuries. Methods Cerebral ischemic pretreatment followed by the cerebral ischemic reperfusion of alternative intervals was performed in the grouped wistar rats by obstructing four blood vessels. The hippocampus neuron damage was measured semiqantitively. Results The hippocampus neuron damage after 3 minutes vessels clipped in the experimental groups was no significant difference compared with which in the blank comparative group. While this damage in the groups of 3 days interval following 6 min ischemic reperfusion was diminished significantly compare with non pretreatment comparative groups and other experimental groups. Conclusion The protective effects of the ischemic pretreatment on the following cerebral ischemic reperfusion injuries are associated with the ischemic pretreatment time, the following ischemic damage time and the interval between the above 2 ischemia.