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Advances in Study of MicroRNA in Inflammatory Bowel Disease

Liu Bing-ron

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Abstract

Inflammatory bowel disease(IBD)is the consequence of an abnormal immune response to environmental factors in genetically susceptible hosts.MicroRNA is a class of noncoding small RNA molecules with the features of about 22 nucleotides,endogenous,and highly conservative,which can regulate a variety of human physiological processes.Recently,unique microRNA expression profiles have been described in IBD,which may help to clarify the pathogenesis of IBD,and have a great significance in diagnosis and targeted therapy of IBD in the future.

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What this paper is about

Inflammatory bowel disease(IBD)is the consequence of an abnormal immune response to environmental factors in genetically susceptible hosts.MicroRNA is a class of noncoding small RNA molecules with the features of about 22 nucleotides,endogenous,and highly conservative,which can regulate a variety of human physiological processes.Recently,unique microRNA expression profiles have been described in IBD,which may help to clarify the pathogenesis of IBD,and have a great significance in diagnosis and targeted therapy of IBD in the future.

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Available abstract

Inflammatory bowel disease(IBD)is the consequence of an abnormal immune response to environmental factors in genetically susceptible hosts.MicroRNA is a class of noncoding small RNA molecules with the features of about 22 nucleotides,endogenous,and highly conservative,which can regulate a variety of human physiological processes.Recently,unique microRNA expression profiles have been described in IBD,which may help to clarify the pathogenesis of IBD,and have a great significance in diagnosis and targeted therapy of IBD in the future.

Key concepts: microRNA, Inflammatory bowel disease, Pathogenesis, Disease, Immune system, Immunology, Biology, Endogeny

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