2009•Unpublished venueRequires access
Effect of Rongban Tongmai Granules on thrombosis and blood viscosity of in vitro rat model of stasis
Z.Z. Yuan, Wenjuan He, Lanfang Zhang, Deng Rui
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Abstract
Purpose To observe the effect of Rongban Tongmai Granules on thrombosis and viscosity of in vitro rat model of stasis,and to study the activating circulation effect of the drug.Methods To observe the effect of the Rongban Tongmai Granules on thrombosis and viscosity of in vitro rat model of stasis,subcutaneous inject rat with epinephrine hydrochloride,and then copy blood model by ice water stimulation in rats.Results According to a continuous 7 days′intragastric administration of Rongban Tongmai Granules,thrombus length of stasis model rats in vitro reduced significantly(P0.05-0.01),wet and dry weight of thrombus reduced significantly(P0.05),the shear rate of the whole viscosity under 100 S-1,30 S-1,5 S-1 decreased significantly as well(P0.05-0.01),and the shear rate of whole viscosity had decreasing tendency under 200 S1.Conclusion Rongban Tongmai Granules can inhibit thrombosis and lower viscosity.