Relationship between FGFR3 and Epithelium Apoptosis after Intestinal Mucosal Ischemia-reperfusion Injury in Mice

Objective To investigate the relationship between fibroblast growth factor receptor 3(FGFR3) and the apoptosis of epithelial cells after intestinal mucosal ischemia-reperfusion injury in mice.Methods An experimental model of intestinal ischemia-reperfusion in mice was established.Intestinal mucosal morphology,apoptosis and proliferation activities of intestinal epithelial cells were observed for wild mice(wild I/R group) and FGFR3-enhanced mice(GFR3+ I/R group) 1,3,6 hours and 1,3 days after reperfusion.Results Progressively severe mucosal injury,dramatically increased epithelial apoptosis and epithelial proliferation were observed 1,3,6 hours after reperfusion.The recovery of mucosal injury and attenuation of epithelial apoptosis were observed 1,3 days after reperfusion.Proliferation activity gradually decreased.The damage and apoptosis in small intestinal epithelium were significantly lower,and proliferation ability was significantly higher in FGFR3+ I/R group than wild I/R group.Conclusion FGFR3 can attenuate the apoptosis of intestinal epithelium and improve the proliferation.FGFR3 plays an important role in intestinal mucosal ischemia-reperfusion damage and repair.