Study on classification of TCM syndromes of Hp-related chronic gastritis

Objective To study the syndromes and syndrome factors of Helicobacter pylori( Hp)-related chronic gastritis,and discuss the expressions of TCM syndromes of Hp infection. Methods The patients with non-atrophic gastritis and atrophic gastritis( each n = 200) were chosen,and their data from TCM four examinations were analyzed by using factor analysis and entropy-reactor of complex system. Results There were 4 syndrome factors related to disease locations of Hp-positive chronic gastritis, including liver,stomach,spleen and gallbladder( gallbladder being given up after clinical and expert questionnaire),and there were 3 of Hp-negative chronic gastritis,including liver,stomach and spleen. There were 9 syndrome factors related to disease nature of Hp-positive or Hp-negative chronic gastritis, including qi deficiency,yin deficiency,yang deficiency,qi stagnation,phlegm,heat,blood stasis,food accumulation and cold. There were 8 basic syndrome types,including para-syndrome of depression-heat in liver and stomach, para-syndrome of spleen-stomach weakness, para-syndrome of damp-heat accumulation,para-syndrome of food stagnation,para-syndrome of spleen cold and stomach heat,parasyndrome of stomach yin deficiency,para-syndrome of liver qi invading stomach and para-syndrome of stasis in stomach collateral. After Chi-square test,the distribution of the syndrome factors related to disease nature had no difference between Hp-positive chronic gastritis and Hp-negative chronic gastritis, but that of basic syndrome types had difference. The results of pairwise comparison showed that Hp infection was significantly correlated to syndrome distribution( P 0. 01),and it was most closely related to para-syndrome of stomach yin deficiency and followed by para-syndrome of spleen-stomach weakness, para-syndrome of damp-heat accumulation and para-syndrome of depression-heat in liver and stomach. Conclusion Hp infection is correlated to dampness and heat,especially to yin deficiency. As a kind of external pathogenic factor,the evil nature of Hp is closely related to heat and dampness and more closely to heat,which is easy to cause impairment of yin.