Analysis on Distribution and Drug Resistance of Mycoplasma and Chlamydia trachomatis in Patients with Non-gonococcal Urethritis

Objective To explore the distribution and drug resistance of mycoplasma and Chlamydia trachomatis in non-gonococcal urethritis (NGU) patients. Methods With culture method, Ureaplasma urealyticum (Uu) and Mycoplasma hominis (Mh) were isolated and identified, and susceptibility testing was performed. Monoclonal antibody with colloidal gold standard method was used to detect Chlamydia according to the original. Results Of 573 clinical specimens, 267 (46.6%) isolates were Ureaplasma urealyticum, 58 (10.1%) isolates were Mycoplasma hominis, and 100 (17.5%) isolates were Chlamydia trachomatis. Mycoplasma showed varying degrees of resistance to the commonly used antibiotics. Conclusions Ureaplasma urealyticum is the main pathogen of non-gonococcal urethritis. Mycoplasma and chlamydia can cause mixed infection. It is of significance to monitor drug resistance of mycoplasma for guiding the rational use of antibiotics.