2013•Zhonghua laonian xin-nao-xueguanbing zazhiRequires access
Effect of Yindanxinnaotong on expression of Bcl-2in hippocampus region of rats after cerebral ischemia reperfusion
Zhongxian Xu
Open publisher page 0 citations
Abstract
Objective To study the mechanism of Yindanxinnaotong in protecting nerve cells against apoptosis in hippocampus CA1region of rats after cerebral ischemia reperfusion(I/R). Methods Forty male SD rats were randomly divided into sham operation group,model group, control group and drug treatment group(10in each group).Rats in control group and drug treatment group were treated with nimodipin and gastric yindanxinnaotong respectively for 7days while those in sham operation group and model group were fed with isovolumic distilled water.A middle cerebral artery occlusion model was established by modified Longa occlusion.Expression of Bcl-2was detected with immunohistochemical staining.Results The expression level of Bcl-2 was significantly higher in drug treatment group,control group and model group than in sham operation group(P0.01),and in drug treatment group and control group than in model group, whats more in drug treatment group than in control group(P0.01).Conclusion The upregulated expression of Bcl-2in brain tissue of rats after cerebral I/R is one of the mechanisms of Yindanxinnaotong in protecting nerve cells against apoptosis.