Expression of VEGF and nm23-H_1 as prognostic factors in cervical carcinoma and clinical implications

[Objective] To evaluate the prognostic significance of VEGF and nm23-H1 expression for patients with cervical carcinoma. [Methods] The expression of VEGF and nm23-H1 were examined by immunohistochemistory S-P staining in 105 cervical carcinoma tissues and 10 chronic cervicitis tissues as well as 20 paracancerous tissues, with follow-up of more than 5 years for the 105 patients with cervical carcinoma after operation. The immunohistochemical data were correlated with relapse, distant metastasis and survival. [Results] No one positive expression of VEGF and 90.0% positive expression of nm23-H1 in chronic cervicitis tissues. 45.0% positive expression of VEGF and 75.0% nm23-H1 in paracancerous tissues.72.4% positive expression of VEGF and 47.6% of nm23-H1 in cervical cancinoma tissues. Positive expression of VEGF and negative expression of nm23-H1 correlated with relapse (P﹤0.05, P﹤0.01) and the development of distant metastasis (P﹤0.01;P﹤0.05) as well as shorter survival (P﹤0.01; P﹤0.05). The expression of VEGF was negatively correlated with the expression of nm23-H1(P﹤0.05). [Conclusion] The results of the study show that the VEGF and nm23-H1 expression are significant prognostic factors for patients with cervical carcinoma and indicate that the high level expression of VEGF and low level expression of nm23-H1 may be associated with the infiltrating development and poor prognosis of cervical carcinoma.